JSTOR Daily

Human Genes for the α and β Chains of Complement C4b-Binding Protein are Closely Linked in a Head-to-Tail Arrangement

C4b-binding protein (C4BP) is an important component in the regulation of the complement system and also binds the anticoagulant vitamin K-dependent protein S. These activities are performed by ...
Nature

Complement system becomes activated by the classical pathway in intracranial aneurysm walls

The classical pathway is activated by C1q-mediated recognition of the target. Further activation of this pathway causes C4b and its cleavage product iC4b to accumulate in the tissues. C4b binds to C2 ...
JSTOR Daily

C4B Deficiency: A Risk Factor for Bacteremia with Encapsulated Organisms

The fourth component of complement (C4) is crucial to the activation of the classical complement pathway, a key defense against invading microorganisms. The two isotypes of C4, C4A and C4B, have very ...
ALZFORUM

Complement Receptor 1 (CR1)

The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...
News Medical

What is the association between interferon genes and complement regulatory protein expressions in SARS-CoV-2 infections?

In a recent study posted to the bioRxiv* preprint server, researchers investigated the expression of complement regulatory proteins (CRPs) in coronavirus disease 2019 (COVID-19) to identify potential ...