This story is part 9 of an occasional series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal ...

Just as a scabbard shields from razor sharp edges, the extracellular chaperone clusterin may ensheathe and sequester lethal forms of Aβ, suggests a Nature Structural and Molecular Biology paper ...

Diagram of how Clusterin brings misfolded proteins and amyloid β into cells where they can be degraded by lysosomes. [Itakura et al., 2020] Researchers in Japan have identified a new quality control ...

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia, with symptoms appearing after age 65. Since carriers of clusterin risk alleles have an increased likelihood of developing ...

Clusterin, also known as apolipoprotein J, is a ubiquitously expressed molecule thought to influence a variety of processes including cell death. In the brain, it accumulates in dying neurons ...

During a study spanning nearly a decade, researchers have linked the protein clusterin -- for the first time -- to many different facets of cardiometabolic syndrome risk through its actions in the ...