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Jan 2, 2026 · In this issue of the JCI, Goala et al. uncovered a mechanistic link between IFN-γ–driven inflammation and disrupted neutrophil homeostasis, revealing that cytokine release …
JCI - About the Journal of Clinical Investigation
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JCI is a Gold Open Access journal and deposits all published research articles in PubMed Central, which satisfies the NIH Public Access Policy and other similar funding agency …
JCI - Volume 135, Issue 24
Dec 15, 2025 · In this issue of the JCI, Miao et al. demonstrated that MCC tumor survival requires neuroendocrine-lineage transcription factors, which are recruited to superenhancers (SEs) …
JCI - Inducible CCR2+ nonclassical monocytes mediate the …
Nov 15, 2024 · Kurihara C, et al. Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte …
JCI - An unexpected role for the brain in the pathogenesis of …
Aug 1, 2025 · Flak JN, et al. Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin. J Clin Invest. 2020;130 (6):2943–2952. View this article via: …
JCI - Isocitrate dehydrogenase mutations suppress STAT1 and …
Mar 20, 2017 · Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among the first genetic alterations observed during the development of lower-grade glioma (LGG). LGG …
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JCI - Endothelial MICU1 protects against vascular inflammation …
JCI Insight. 2022;7 (4):e154447. View this article via: JCI Insight PubMed Google Scholar Singh R, et al. Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of …